Ontology highlight
ABSTRACT:
SUBMITTER: Lee H
PROVIDER: S-EPMC6398476 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Lee Hyunjung H Eskin Suzanne G SG Ono Shoichiro S Zhu Cheng C McIntire Larry V LV
Journal of cell science 20190204 4
The actin cytoskeleton is subjected to dynamic mechanical forces over time and the history of force loading may serve as mechanical preconditioning. While the actin cytoskeleton is known to be mechanosensitive, the mechanisms underlying force regulation of actin dynamics still need to be elucidated. Here, we investigated actin depolymerization under a range of dynamic tensile forces using atomic force microscopy. Mechanical loading by cyclic tensile forces induced significantly enhanced bond lif ...[more]