Curvature-dependent constraints drive remodeling of epithelia.
Ontology highlight
ABSTRACT:
SUBMITTER: Maechler FA
PROVIDER: S-EPMC6398478 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Curvature-dependent constraints drive remodeling of epithelia.
Maechler Florian A FA Allier Cédric C Roux Aurélien A Tomba Caterina C
Journal of cell science 20190124 4
Epithelial tissues function as barriers that separate the organism from the environment. They usually have highly curved shapes, such as tubules or cysts. However, the processes by which the geometry of the environment and the cell's mechanical properties set the epithelium shape are not yet known. In this study, we encapsulated two epithelial cell lines, MDCK and J3B1A, into hollow alginate tubes and grew them under cylindrical confinement forming a complete monolayer. MDCK monolayers detached ...[more]
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