Ontology highlight
ABSTRACT:
SUBMITTER: Yang Q
PROVIDER: S-EPMC6398506 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Yang Qiqi Q Yan Chuan C Wang Xu X Gong Zhiyuan Z
Disease models & mechanisms 20190227 2
Cancer cachexia affects up to 80% of patients with advanced solid cancer and leads to excessive muscle wasting. Here, using an inducible zebrafish hepatocellular carcinoma (HCC) model driven by oncogenic <i>kras<sup>G12V</sup></i> , we observed a progressive muscle-wasting phenotype in adult zebrafish, characterized by significant loss of body weight and muscle fibers. By differential feeding, we observed that overfeeding caused fatty liver, accelerated carcinogenesis and muscle wasting. Interes ...[more]