Utility of the number needed to treat in paediatric haematological cancer randomised controlled treatment trials: a systematic review.

ABSTRACT:

Objectives

The primary objective was to assess the utility of the number needed to treat (NNT) to inform decision-making in the context of paediatric oncology and to calculate the NNT in all superiority, parallel, paediatric haematological cancer, randomised controlled trials (RCTs), with a comparison to the threshold NNT as a measure of clinical significance.

Design

Systematic review DATA SOURCES: MEDLINE, EMBASE and the Cochrane Childhood Cancer Group Specialized Register through CENTRAL from inception to August 2018.

Eligibility criteria for selecting studies

Superiority, parallel RCTs of haematological malignancy treatments in paediatric patients that assessed an outcome related to survival, relapse or remission; reported a sample size calculation with a delta val

SUBMITTER: Hasan H 

PROVIDER: S-EPMC6398916 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature