Ontology highlight
ABSTRACT:
SUBMITTER: Prowse TA
PROVIDER: S-EPMC6398975 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Prowse Thomas Aa TA Adikusuma Fatwa F Cassey Phillip P Thomas Paul P Ross Joshua V JV
eLife 20190215
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could be incorporated within gene-drive designs. We introduce a novel gene-drive strategy termed Y-CHromosome deletion using Orthogonal Programmable Endonucleases (Y-CHOPE), incorporating a programmable endonuclease that 'shreds' the Y chromosome, there ...[more]