Ontology highlight
ABSTRACT:
SUBMITTER: McSharry SS
PROVIDER: S-EPMC6399233 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
McSharry Saoirse S SS Beitel Greg J GJ
Nature communications 20190304 1
Although well known for its role in apoptosis, the executioner caspase DrICE has a non-apoptotic function that is required for elongation of the epithelial tubes of the Drosophila tracheal system. Here, we show that DrICE acts downstream of the Hippo Network to regulate endocytic trafficking of at least four cell polarity, cell junction and apical extracellular matrix proteins involved in tracheal tube size control: Crumbs, Uninflatable, Kune-Kune and Serpentine. We further show that tracheal ce ...[more]