Unknown

Dataset Information

0

Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity.


ABSTRACT: Many cancer therapies are being developed for the induction of durable anti-tumor immunity, especially for malignant tumors. The activation of antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), can bridge innate and adaptive immune responses against tumors. However, APCs have an immunosuppressive phenotype and reversing it for effective tumor-specific antigen presenting is critical in developing new cancer treatment strategies. We previously developed a novel cryo-thermal therapy to treat malignant melanoma in a mouse model; long-term survival and durable anti-tumor immunity were achieved, but the mechanism involved was unclear. This study revealed cryo-thermal therapy-induced macrophage polarization to the M1 phenotype and modulated the phenotypic and functional maturation of DCs with high expression of co-stimulatory molecules, increased pro-inflammatory cytokine production, and downregulated immuno-inhibitory molecule expression. Further, we observed CD4+ T-cell differentiation into Th1 and cytotoxic T-cell sub-lineages and generation of cytotoxic CD8+ T cells, in which M1 macrophage polarization had a direct, important role. The results indicated that cryo-thermal-induced macrophage polarization to the M1 phenotype was essential to mediate durable anti-tumor immunity, leading to long-term survival. Thus, cryo-thermal therapy is a promising strategy to reshape host immunosuppression, trigger persistent memory immunity for tumor eradication, and inhibit metastasis in the long term.

SUBMITTER: He K 

PROVIDER: S-EPMC6399266 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity.

He Kun K   Jia Shengguo S   Lou Yue Y   Liu Ping P   Xu Lisa X LX  

Cell death & disease 20190304 3


Many cancer therapies are being developed for the induction of durable anti-tumor immunity, especially for malignant tumors. The activation of antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), can bridge innate and adaptive immune responses against tumors. However, APCs have an immunosuppressive phenotype and reversing it for effective tumor-specific antigen presenting is critical in developing new cancer treatment strategies. We previously developed a novel cryo-  ...[more]

Similar Datasets

| S-EPMC4891716 | biostudies-literature
2016-05-12 | PXD003136 | Pride
| S-EPMC6029830 | biostudies-other
| S-EPMC8268875 | biostudies-literature
| S-EPMC7966525 | biostudies-literature
| S-EPMC4860887 | biostudies-literature
| S-EPMC3702174 | biostudies-other
2024-03-02 | GSE259010 | GEO
| S-EPMC7281193 | biostudies-literature
| S-EPMC8280123 | biostudies-literature