Ontology highlight
ABSTRACT:
SUBMITTER: Latendorf T
PROVIDER: S-EPMC6399351 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Latendorf Ties T Gerstel Ulrich U Wu Zhihong Z Bartels Joachim J Becker Alexander A Tholey Andreas A Schröder Jens-Michael JM
Scientific reports 20190304 1
In the search for potential mechanisms underlying the remarkable resistance of healthy skin against infection by soil bacteria like Pseudomonas (P.) aeruginosa we identified fragments of the intrinsically disordered protein hornerin as potent microbicidal agents in the stratum corneum. We found that, independent of the amino acid (AA)-sequence, any tested linear cationic peptide containing a high percentage of disorder-promoting AA and a low percentage of order-promoting AA is a potent microbici ...[more]