Testosterone Reduces Fear and Causes Drastic Hypomethylation of Arginine Vasopressin Promoter in Medial Extended Amygdala of Male Mice.
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ABSTRACT:
SUBMITTER: Tong WH
PROVIDER: S-EPMC6399424 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Testosterone Reduces Fear and Causes Drastic Hypomethylation of Arginine Vasopressin Promoter in Medial Extended Amygdala of Male Mice.
Tong Wen Han WH Abdulai-Saiku Samira S Vyas Ajai A
Frontiers in behavioral neuroscience 20190226
Testosterone reduces anxiety-like behaviors in rodents and increases exploration of anxiogenic parts of the environment. Effects of testosterone on innate defensive behaviors remain understudied. Here, we demonstrate that exogenous testosterone reduces aversion to cat odor in male mice. This is reflected as increased exploration of area containing cat urine when castrated male mice are supplied with exogenous testosterone. We also report that exogenous testosterone leads to DNA hypomethylation o ...[more]
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