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Intrinsic default-executive coupling of the creative aging brain.

ABSTRACT: Creativity refers to the ability to generate novel associations and has been linked to better problem-solving and real-world functional abilities. In younger adults, creative cognition has been associated with functional connectivity among brain networks implicated in executive control [fronto-parietal network (FPN) and salience network (SN)] and associative or elaborative processing default network (DN). Here, we investigate whether creativity is associated with the intrinsic network architecture of the brain and how these associations may differ for younger and older adults. Young (mean age: 24.76, n = 22) and older (mean age: 70.03, n = 44) adults underwent multi-echo functional magnetic resonance image scanning at rest and completed a divergent-thinking task to assess creative cognition outside the scanner. Divergent thinking in older adults, compared to young adults, was associated with functional connectivity between the default and both executive control networks (FPN and SN) as well as more widespread default-executive coupling. Finally, the ventromedial prefrontal cortex appears to be a critical node involved in within- and between-network connectivity associated with creative cognition in older adulthood. Patterns of intrinsic network coupling revealed here suggest a putative neural mechanism underlying a greater role for mnemonic processes in creative cognition in older adulthood.

SUBMITTER: Adnan A

PROVIDER: S-EPMC6399613 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Intrinsic default-executive coupling of the creative aging brain.

Adnan Areeba A Beaty Roger R Lam Jaeger J Spreng R Nathan RN Turner Gary R GR

Social cognitive and affective neuroscience 20190301 3

Creativity refers to the ability to generate novel associations and has been linked to better problem-solving and real-world functional abilities. In younger adults, creative cognition has been associated with functional connectivity among brain networks implicated in executive control [fronto-parietal network (FPN) and salience network (SN)] and associative or elaborative processing default network (DN). Here, we investigate whether creativity is associated with the intrinsic network architectu ...[more]

PMID: 30783663

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Project description:The default mode network (DMN) is a widely distributed, intrinsic brain network thought to play a crucial role in internally directed cognition. The present study employs stereo-EEG in 13 human patients, obtaining high resolution neural recordings across multiple canonical DMN regions during two processes that have been associated with creative thinking: spontaneous and divergent thought. We probe these two DMN-associated higher cognitive functions through mind wandering and alternate uses tasks, respectively. Our results reveal DMN recruitment during both tasks, as well as a task-specific dissociation in spatiotemporal response dynamics. When compared to the fronto-parietal network, DMN activity was characterized by a stronger increase in gamma band power (30-70 Hz) coupled with lower theta band power (4-8 Hz). The difference in activity between the two networks was especially strong during the mind wandering task. Within the DMN, we found that the tasks showed different dynamics, with the alternate uses task engaging the DMN more during the initial stage of the task, and mind wandering in the later stage. Gamma power changes were mainly driven by lateral DMN sites, while theta power displayed task-specific effects. During alternate uses task, theta changes did not show spatial differences within the DMN, while mind wandering was associated to an early lateral and late dorsomedial DMN engagement. Furthermore, causal manipulations of DMN regions using direct cortical stimulation preferentially decreased the originality of responses in the alternative uses task, without affecting fluency or mind wandering. Our results suggest that DMN activity is flexibly modulated as a function of specific cognitive processes and supports its causal role in divergent thinking. These findings shed light on the neural constructs supporting different forms of cognition and provide causal evidence for the role of DMN in the generation of original connections among concepts.

Dataset Information

Intrinsic default-executive coupling of the creative aging brain.

Publications

Intrinsic default-executive coupling of the creative aging brain.

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