Ontology highlight
ABSTRACT:
SUBMITTER: Butali A
PROVIDER: S-EPMC6400042 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Human molecular genetics 20190301 6
Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or near genome-wide significance on chromosomes 2 (near CTNNA2) and 19 (near SULT2A1). In situ hybridization of Sult2a1 in mice show ...[more]