Ontology highlight
ABSTRACT:
SUBMITTER: Gorvin CM
PROVIDER: S-EPMC6400049 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gorvin Caroline M CM Newey Paul J PJ Rogers Angela A Stokes Victoria V Neville Matt J MJ Lines Kate E KE Ntali Georgia G Lees Peter P Morrison Patrick J PJ Singhellakis Panagiotis N PN Malandrinou Fotini Ch FC Karavitaki Niki N Grossman Ashley B AB Karpe Fredrik F Thakker Rajesh V RV
Human molecular genetics 20190301 6
Prolactinomas are the most frequent type of pituitary tumors, which represent 10-20% of all intracranial neoplasms in humans. Prolactinomas develop in mice lacking the prolactin receptor (PRLR), which is a member of the cytokine receptor superfamily that signals via Janus kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) or phosphoinositide 3-kinase-Akt (PI3K-Akt) pathways to mediate changes in transcription, differentiation and proliferation. To elucidate the role of the ...[more]