Choosing your (Friedel) mates wisely: grouping data sets to improve anomalous signal.
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ABSTRACT:
SUBMITTER: Foos N
PROVIDER: S-EPMC6400255 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Choosing your (Friedel) mates wisely: grouping data sets to improve anomalous signal.
Foos Nicolas N Cianci Michele M Nanao Max H MH
Acta crystallographica. Section D, Structural biology 20190131 Pt 2
Single-wavelength anomalous diffraction (SAD) phasing from multiple crystals can be especially challenging in samples with weak anomalous signals and/or strong non-isomorphism. Here, advantage is taken of the combinatorial diversity possible in such experiments to study the relationship between merging statistics and downstream metrics of phasing signals. It is furthermore shown that a genetic algorithm (GA) can be used to optimize the grouping of data sets to enhance weak anomalous signals base ...[more]
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