Ontology highlight
ABSTRACT:
SUBMITTER: Michels BE
PROVIDER: S-EPMC6400532 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20190221 3
Constitutive Wnt activation upon loss of <i>Adenoma polyposis coli</i> (<i>APC</i>) acts as main driver of colorectal cancer (CRC). Targeting Wnt signaling has proven difficult because the pathway is crucial for homeostasis and stem cell renewal. To distinguish oncogenic from physiological Wnt activity, we have performed transcriptome and proteome profiling in isogenic human colon organoids. Culture in the presence or absence of exogenous ligand allowed us to discriminate receptor-mediated signa ...[more]