Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.
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ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC6400540 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.
Liu Jing J Jiang Wenna W Zhao Kaili K Wang Hongwei H Zhou Tianxing T Bai Weiwei W Wang Xiuchao X Zhao Tiansuo T Huang Chongbiao C Gao Song S Qin Tai T Yu Wenwen W Yang Bo B Li Xin X Fu Danqi D Tan Wei W Yang Shengyu S Ren He H Hao Jihui J
The Journal of experimental medicine 20190207 3
Pancreatic ductal adenocarcinoma (PDAC) is a highly immune-suppressive tumor with a low response rate to single checkpoint blockade therapy. ETS homologous factor (EHF) is a tumor suppressor in PDAC. Here, we report a novel function of EHF in pancreatic cancer immune microenvironment editing and efficacy prediction for anti-PD1 therapy. Our findings support that the deficiency of tumoral EHF induced the accumulation of regulatory T (T reg) cells and myeloid-derived suppressor cells (MDSCs) and a ...[more]
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