Ontology highlight
ABSTRACT:
SUBMITTER: Gunawan F
PROVIDER: S-EPMC6400548 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gunawan Felix F Gentile Alessandra A Fukuda Ryuichi R Tsedeke Ayele Taddese AT Jiménez-Amilburu Vanesa V Ramadass Radhan R Iida Atsuo A Sehara-Fujisawa Atsuko A Stainier Didier Y R DYR
The Journal of cell biology 20190111 3
Elucidating the morphogenetic events that shape vertebrate heart valves, complex structures that prevent retrograde blood flow, is critical to understanding valvular development and aberrations. Here, we used the zebrafish atrioventricular (AV) valve to investigate these events in real time and at single-cell resolution. We report the initial events of collective migration of AV endocardial cells (ECs) into the extracellular matrix (ECM), and their subsequent rearrangements to form the leaflets. ...[more]