An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome.
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ABSTRACT:
SUBMITTER: Richardson TG
PROVIDER: S-EPMC6400585 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome.
Richardson Tom G TG Harrison Sean S Hemani Gibran G Davey Smith George G
eLife 20190305
The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (p<5×10<sup>-05</sup>) derived from GWAS and 551 heritable traits from the UK Biobank study (N = 334,398). Findings can be investigated using a web application (http://mrcieu.mrsoftware.org/PRS_atlas/), which we envisage will help uncover both known and n ...[more]
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