Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Z
PROVIDER: S-EPMC6401194 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zheng Zhuojun Z Zheng Xiao X Zhu Yuandong Y Gu Xiaoyan X Gu Weiying W Xie Xiaobao X Hu Wenwei W Jiang Jingting J
Molecular therapy : the journal of the American Society of Gene Therapy 20190201 3
Erbin has been shown to have significant effects on the development of solid tumors. However, little is known about its function and regulatory mechanism in hematological malignancies. The biological function of Erbin on cell proliferation was measured in vitro and in vivo. The predicted target of Erbin was validated by dual-luciferase reporter assay and rescue experiment. We found that overexpression of Erbin could inhibit the cell proliferation and promote the cell differentiation of acute mye ...[more]