Ontology highlight
ABSTRACT:
SUBMITTER: Kim D
PROVIDER: S-EPMC6401226 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kim Dongkyun D Le Hongnga T HT Nguyen Quang Tam QT Kim Sohee S Lee Juyeun J Min Booki B
Journal of immunology (Baltimore, Md. : 1950) 20190130 6
IL-27 regulates immune responses in inflammation. The underlying mechanism of IL-27 functions has long been attributed to its ability to induce IL-10 production in activated CD4 T cells. In this study, we report that Foxp3<sup>+</sup> regulatory T cells (Tregs) are the main target cells of IL-27, mediating its immunoregulatory functions in vivo. Systemically delivered IL-27 efficiently prevents the development of experimental autoimmune encephalomyelitis, an autoimmune inflammation in the CNS. H ...[more]