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Radiated and guided optical waves of a magnetic dipole-nanofiber system.

ABSTRACT: Nanophotonics-photonic structures with subwavelength features-allow accessing high intensity and localized electromagnetic field and hence is an ideal platform for investigating and exploiting strong lightmatter interaction. In particular, such a strong light-matter interaction requires investigating the interaction of a magnetic dipole with the electromagnetic field- a less-explored topic, which has usually been ignored within the framework of electric dipole approximation. Motivated by recent advances in the emerging field of multipolar nanophotonics, here we develop an analytical model that provides a new insight into analyzing a magnetic dipole and a nanofiber. This method enables us to examine the effect of second term in the multipolar expansion of light-matter interaction, magnetic dipole approximation, with individual guided and radiation modes of the nanofiber. This is a critical key in developing nanophotonic integrated devices based on magnetic nature of light for super-imaging, biosensing, and optical computing.

SUBMITTER: Atakaramians S

PROVIDER: S-EPMC6401418 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Radiated and guided optical waves of a magnetic dipole-nanofiber system.

Atakaramians Shaghik S Dong Feng Q FQ Monro Tanya M TM Afshar V Shahraam S

Scientific reports 20190305 1

Nanophotonics-photonic structures with subwavelength features-allow accessing high intensity and localized electromagnetic field and hence is an ideal platform for investigating and exploiting strong lightmatter interaction. In particular, such a strong light-matter interaction requires investigating the interaction of a magnetic dipole with the electromagnetic field- a less-explored topic, which has usually been ignored within the framework of electric dipole approximation. Motivated by recent ...[more]

PMID: 30837597

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Project description:BACKGROUND:MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and blood-brain barrier opening. However, the large financial costs involved in developing preclinical MRgFUS systems represent a barrier to research groups interested in developing new techniques and applications. We aim to mitigate these challenges by detailing a validated, open-source preclinical MRgFUS system capable of delivering thermal and mechanical FUS in a quantifiable and repeatable manner under real-time MRI guidance. METHODS:A hardware and software package was developed that includes closed-loop feedback controlled thermometry code and CAD drawings for a therapy table designed for a preclinical MRI scanner. For thermal treatments, the modular software uses a proportional integral derivative controller to maintain a precise focal temperature rise in the target given input from MR phase images obtained concurrently. The software computes the required voltage output and transmits it to a FUS transducer that is embedded in the delivery table within the magnet bore. The delivery table holds the FUS transducer, a small animal and its monitoring equipment, and a transmit/receive RF coil. The transducer is coupled to the animal via a water bath and is translatable in two dimensions from outside the magnet. The transducer is driven by a waveform generator and amplifier controlled by real-time software in Matlab. MR acoustic radiation force imaging is also implemented to confirm the position of the focus for mechanical and thermal treatments. RESULTS:The system was validated in tissue-mimicking phantoms and in vivo during murine tumor hyperthermia treatments. Sonications were successfully controlled over a range of temperatures and thermal doses for up to 20 min with minimal temperature overshoot. MR thermometry was validated with an optical temperature probe, and focus visualization was achieved with acoustic radiation force imaging. CONCLUSIONS:We developed an MRgFUS platform for small-animal treatments that robustly delivers accurate, precise, and controllable sonications over extended time periods. This system is an open source and could increase the availability of low-cost small-animal systems to interdisciplinary researchers seeking to develop new MRgFUS applications and technology.

Dataset Information

Radiated and guided optical waves of a magnetic dipole-nanofiber system.

Publications

Radiated and guided optical waves of a magnetic dipole-nanofiber system.

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