Ontology highlight
ABSTRACT:
SUBMITTER: Tang L
PROVIDER: S-EPMC6401502 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tang Longguang L Yang Zhen Z Zhou Zijian Z Ma Ying Y Kiesewetter Dale O DO Wang Zhantong Z Fan Wenpei W Zhu Shoujun S Zhang Mingru M Tian Rui R Lang Lixin L Niu Gang G Zhang Xianzhong X Chen Xiaoyuan X
Theranostics 20190214 5
It remains a major challenge to achieve precise on-demand drug release. Here, we developed a modular nanomedicine integrated with logic-gated system enabling programmable drug release for on-demand chemotherapy. <b>Methods:</b> We employed two different logical AND gates consisting of four interrelated moieties to construct the nanovesicles, denoted as v-A-CED<sub>2</sub>, containing oxidation-responsive nanovesicles (v), radical generators (A), and Edman linker conjugated prodrugs (CED<sub>2</s ...[more]