Ontology highlight
ABSTRACT:
SUBMITTER: Duan Z
PROVIDER: S-EPMC6402293 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Duan Zhijian Z Chinn Danielle D Tu Mei-Juan MJ Zhang Qian-Yu QY Huynh Jasmine J Chen Justin J Mack Philip P Yu Ai-Ming AM Kim Edward J EJ
Translational oncology 20190304 4
The BCL-2 family of proteins, including anti-apoptotic members BCL-2, BCL-XL and MCL-1, are part of a complex network that controls apoptosis. BH3-mimetics such as ABT-263 inhibit anti-apoptotic BCL-2 proteins and have been developed as potential cancer therapeutics. Aurora Kinase A (AKA) is over-expressed in pancreatic cancer (PC) and controls G2-M transition during mitosis and AKA inhibitors have been developed that induce mitotic arrest. We hypothesized that mitotic arrest induced by AKA inhi ...[more]