Ontology highlight
ABSTRACT:
SUBMITTER: Boursier ME
PROVIDER: S-EPMC6402343 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Boursier Michelle E ME Combs Joshua B JB Blackwell Helen E HE
ACS chemical biology 20190201 2
The RhlR quorum sensing (QS) receptor in the pathogen Pseudomonas aeruginosa plays a prominent role in infection, and both antagonism and agonism of RhlR have been shown to negatively regulate important virulence phenotypes. Non-native lactone ligands are known to modulate RhlR activity, but their utility as chemical probes is relatively limited due to hydrolytic instability. Herein, we report our design and biological evaluation of a suite of hybrid AHL analogs with structures merging (1) featu ...[more]