Ontology highlight
ABSTRACT:
SUBMITTER: Ip JPK
PROVIDER: S-EPMC6402579 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nature reviews. Neuroscience 20180601 6
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2). Almost two decades of research into RTT have greatly advanced our understanding of the function and regulation of the multifunctional protein MeCP2. Here, we review recent advances in understanding how loss of MeCP2 impacts different stages of brain development, discuss recent findings demonstrating the molecular role of MeCP2 as a transcriptional repressor, assess ...[more]