An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium.

ABSTRACT: While organotypic approaches promise increased relevance through the inclusion of increased complexity (e.g., 3D extracellular microenvironment, structure/function relationships, presence of multiple cell types), cell source is often overlooked. Induced pluripotent stem cell (iPSC)-derived cells are potentially more physiologically relevant than cell lines, while also being less variable than primary cells, and recent advances have made them commercially available at costs similar to cell lines. Here, the use of induced pluripotent stem cell-derived endothelium for the generation of a functional microvessel model is demonstrated. High precision structural and microenvironmental control afforded by the design approach synergizes with the advantages of iPSC to produce microvessels for modeli

SUBMITTER: Ingram PN 

PROVIDER: S-EPMC6402823 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature