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Predicting text reading skills at age 8?years in children born preterm and at term.

ABSTRACT: BACKGROUND:Children born preterm are at risk for developing reading difficulties and for decrements in other cognitive skills compared to children born at term. AIMS:To assess how domains of function, often negatively impacted by preterm birth, predict reading development in children born preterm and at term. STUDY DESIGN:Longitudinal descriptive cohort study. SUBJECTS:Preterm (n?=?48; gestational age 22-32?weeks, 30 males) and term (n?=?41, 18 males) participants were assessed at age 6?years on a battery of verbal and non-verbal cognitive skills and reassessed at age 8 using the Gray Oral Reading Tests-5. Linear regressions assessed the contributions of phonological awareness, language, executive function, and non-verbal IQ at age 6 to reading outcome at age 8. RESULTS:Children born preterm had lower scores than children born at term on all measures (Cohen's d from 0.46 to 1.08, all p?

SUBMITTER: Borchers LR

PROVIDER: S-EPMC6402954 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Predicting text reading skills at age 8 years in children born preterm and at term.

Borchers Lauren R LR Bruckert Lisa L Travis Katherine E KE Dodson Cory K CK Loe Irene M IM Marchman Virginia A VA Feldman Heidi M HM

Early human development 20190129

<h4>Background</h4>Children born preterm are at risk for developing reading difficulties and for decrements in other cognitive skills compared to children born at term.<h4>Aims</h4>To assess how domains of function, often negatively impacted by preterm birth, predict reading development in children born preterm and at term.<h4>Study design</h4>Longitudinal descriptive cohort study.<h4>Subjects</h4>Preterm (n = 48; gestational age 22-32 weeks, 30 males) and term (n = 41, 18 males) participants we ...[more]

PMID: 30708270

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Project description:Children born preterm (PT) are at risk for white matter injuries based on complications of prematurity. They learn to read but on average perform below peers born full term (FT). Studies have yet to establish whether properties of white matter pathways at the onset of learning to read are associated with individual variation later in reading development in PT children. Here, we asked whether fractional anisotropy (FA) at age 6 years is associated with reading outcome at age 8 years in PT children in the same pathways as previously demonstrated in a sample of FT children. PT (n = 34, mean gestational age = 29.5 weeks) and FT children (n = 37) completed diffusion MRI and standardized measures of non-verbal IQ, language, and phonological awareness at age 6 years. Reading skills were assessed at age 8 years. Mean tract-FA was extracted from pathways that predicted reading outcome in children born FT: left arcuate fasciculus (Arc), bilateral superior longitudinal fasciculus (SLF), and left inferior cerebellar peduncle (ICP). We explored associations in additional pathways in the PT children: bilateral inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, and uncinate fasciculus. Linear regression models examined whether the prediction of reading outcome at age 8 years based on mean tract-FA at age 6 years was moderated by birth group. Children born PT and FT did not differ significantly in tract-FA at age 6 years or in reading at age 8 years. Sex, socioeconomic status, and non-verbal IQ at age 6 years were associated with reading outcome and were included as covariates in all models. Birth group status significantly moderated associations between reading outcome and mean tract-FA only in the left Arc, right SLF, and left ICP, before and after consideration of pre-literacy skills. Microstructural properties of these cerebral and cerebellar pathways predicted later reading outcome in FT but not in PT children. Children born PT may rely on alternative pathways to achieve fluent reading. These findings have implications for plasticity of neural organization after early white matter injury.

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Predicting text reading skills at age 8?years in children born preterm and at term.

Publications

Predicting text reading skills at age 8 years in children born preterm and at term.

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Dataset Information

Predicting text reading skills at age 8?years in children born preterm and at term.

Publications

Predicting text reading skills at age 8 years in children born preterm and at term.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Predicting text reading skills at age 8 years in children born preterm and at term.