Ontology highlight
ABSTRACT:
SUBMITTER: Shae D
PROVIDER: S-EPMC6402974 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Shae Daniel D Becker Kyle W KW Christov Plamen P Yun Dong Soo DS Lytton-Jean Abigail K R AKR Sevimli Sema S Ascano Manuel M Kelley Mark M Johnson Douglas B DB Balko Justin M JM Wilson John T JT
Nature nanotechnology 20190121 3
Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising class of immunotherapeutics that activate innate immunity to increase tumour immunogenicity. However, the efficacy of CDNs is limited by drug delivery barriers, including poor cellular targeting, rapid clearance and inefficient transport to the cytosol where STING is localized. Here, we describe STING-activating nanoparticles (STING-NPs)-rationally designed polymersomes for enhanced cytosolic delivery of ...[more]