Ontology highlight
ABSTRACT:
SUBMITTER: Michalska K
PROVIDER: S-EPMC6403000 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Michalska Karolina K Zhang Kaiming K March Zachary M ZM Hatzos-Skintges Catherine C Pintilie Grigore G Bigelow Lance L Castellano Laura M LM Miles Leann J LJ Jackrel Meredith E ME Chuang Edward E Jedrzejczak Robert R Shorter James J Chiu Wah W Joachimiak Andrzej A
Structure (London, England : 1993) 20181227 3
Hsp104 is an AAA+ protein disaggregase with powerful amyloid-remodeling activity. All nonmetazoan eukaryotes express Hsp104 while eubacteria express an Hsp104 ortholog, ClpB. However, most studies have focused on Hsp104 from Saccharomyces cerevisiae and ClpB orthologs from two eubacterial species. Thus, the natural spectrum of Hsp104/ClpB molecular architectures and protein-remodeling activities remains largely unexplored. Here, we report two structures of Hsp104 from the thermophilic fungus Cal ...[more]