Dataset Information

The Brain Imaging Collaboration Suite (BrICS): A Cloud Platform for Integrating Whole-Brain Spectroscopic MRI into the Radiation Therapy Planning Workflow.

ABSTRACT: Glioblastoma has poor prognosis with inevitable local recurrence despite aggressive treatment with surgery and chemoradiation. Radiation therapy (RT) is typically guided by contrast-enhanced T1-weighted magnetic resonance imaging (MRI) for defining the high-dose target and T2-weighted fluid-attenuation inversion recovery MRI for defining the moderate-dose target. There is an urgent need for improved imaging methods to better delineate tumors for focal RT. Spectroscopic MRI (sMRI) is a quantitative imaging technique that enables whole-brain analysis of endogenous metabolite levels, such as the ratio of choline-to-N-acetylaspartate. Previous work has shown that choline-to-N-acetylaspartate ratio accurately identifies tissue with high tumor burden beyond what is seen on standard imaging and can predict regions of metabolic abnormality that are at high risk for recurrence. To facilitate efficient clinical implementation of sMRI for RT planning, we developed the Brain Imaging Collaboration Suite (BrICS; https://brainimaging.emory.edu/brics-demo), a cloud platform that integrates sMRI with standard imaging and enables team members from multiple departments and institutions to work together in delineating RT targets. BrICS is being used in a multisite pilot study to assess feasibility and safety of dose-escalated RT based on metabolic abnormalities in patients with glioblastoma (Clinicaltrials.gov NCT03137888). The workflow of analyzing sMRI volumes and preparing RT plans is described. The pipeline achieved rapid turnaround time by enabling team members to perform their delegated tasks independently in BrICS when their clinical schedules allowed. To date, 18 patients have been treated using targets created in BrICS and no severe toxicities have been observed.

SUBMITTER: Gurbani S

PROVIDER: S-EPMC6403040 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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The Brain Imaging Collaboration Suite (BrICS): A Cloud Platform for Integrating Whole-Brain Spectroscopic MRI into the Radiation Therapy Planning Workflow.

Gurbani Saumya S Weinberg Brent B Cooper Lee L Mellon Eric E Schreibmann Eduard E Sheriff Sulaiman S Maudsley Andrew A Goryawala Mohammed M Shu Hui-Kuo HK Shim Hyunsuk H

Tomography (Ann Arbor, Mich.) 20190301 1

Glioblastoma has poor prognosis with inevitable local recurrence despite aggressive treatment with surgery and chemoradiation. Radiation therapy (RT) is typically guided by contrast-enhanced T1-weighted magnetic resonance imaging (MRI) for defining the high-dose target and T2-weighted fluid-attenuation inversion recovery MRI for defining the moderate-dose target. There is an urgent need for improved imaging methods to better delineate tumors for focal RT. Spectroscopic MRI (sMRI) is a quantitati ...[more]

PMID: 30854456

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Project description:A new IoT (Internet of Things) analysis platform is designed based on edge computing and cloud collaboration from the perspective of organizational behavior, to fundamentally understand the relationship between enterprise career maturity and career planning, and meet the actual needs of enterprises. The performance of the proposed model is further determined according to the characteristic of the edge near data sources, with the help of factor analysis, and through the study and analysis of relevant enterprise data. The model is finally used to analyze the relationship between enterprise career maturity and career planning through simulation experiments. The research results prove that career maturity positively affects career planning, and vocational delay of gratification plays a mediating role in career maturity and career planning. Besides, the content of career choice in career maturity is influenced by mental acuity, result acuity and loyalty. The experimental results indicate that when the load at both ends of the edge and cloud exceeds 80%, the edge delay of the IoT analysis platform based on edge computing and cloud collaboration is 10s faster than that of other models. Meanwhile, the system slowdown is reduced by 36% while the stability is increased when the IoT analysis platform analyzes data. The results of the edge-cloud collaboration scheduling scheme are similar to all scheduling to the edge end, which saves 19% of the time compared with cloud computing to the cloud end. In Optical Character Recognition and Aeneas, compared with the single edge-cloud coordination mode, the model with the Nesterov Accelerated Gradient algorithm achieves the optimal performance. Specifically, the communication delay is reduced by about 25% on average, and the communication time decreased by 61% compared with cloud computing to the edge end. This work has significant reference value for analyzing the relationship between enterprise psychology, behavior, and career planning.

Dataset Information

The Brain Imaging Collaboration Suite (BrICS): A Cloud Platform for Integrating Whole-Brain Spectroscopic MRI into the Radiation Therapy Planning Workflow.

Publications

The Brain Imaging Collaboration Suite (BrICS): A Cloud Platform for Integrating Whole-Brain Spectroscopic MRI into the Radiation Therapy Planning Workflow.

Similar Datasets

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