Ontology highlight
ABSTRACT:
SUBMITTER: Campos B
PROVIDER: S-EPMC6403212 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Campos Bruno B Rivetti Claudia C Tauler Roma R Piña Benjamin B Barata Carlos C
Scientific reports 20190306 1
Serotonin has a pivotal function regulating development, growth, reproduction and behavior in animals. In this paper, we studied the deregulatory effects of the deprivation of serotonin in Daphnia magna TRH CRISPR-Cas9 mutants. Bi-allelic in-del THR mutants and, to a lesser extent, mono-allelic ones grew less, reproduced later, and produced smaller clutches than wild type clones. Transcriptomic and functional gene analyses showed a down-regulation of growth/molting and energy metabolism signalin ...[more]