Ontology highlight
ABSTRACT:
SUBMITTER: Ou J
PROVIDER: S-EPMC6403256 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ou Juanjuan J Peng Yuan Y Yang Weiwen W Zhang Yue Y Hao Jie J Li Fu F Chen Yanrong Y Zhao Yang Y Xie Xiong X Wu Shuang S Zha Lin L Luo Xi X Xie Ganfeng G Wang Liting L Sun Wei W Zhou Qi Q Li Jianjun J Liang Houjie H
Nature communications 20190306 1
The efficacy of Fluorouracil (FU) in the treatment of colorectal cancer (CRC) is greatly limited by drug resistance. Autophagy has been implicated in chemoresistance, but the role of selective autophagic degradation in regulating chemoresistance remains unknown. In this study, we revealed a critical role of ABHD5 in charging CRC sensitivity to FU via regulating autophagic uracil yield. We demonstrated that ABHD5 localizes to lysosome and interacts with PDIA5 to prevent PDIA5 from interacting wit ...[more]