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Scaling and correlation properties of RR and QT intervals at the cellular level.


ABSTRACT: We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis and Poincaré plots reveal remarkable similarities between the ECG and hiPSC-CM data. In particular, no statistically significant difference was found in the short- and long-term scaling exponents ?1 and ?2 of RR and QT intervals and their cellular equivalences. Previously unknown scaling properties of FPDs of hiPSC-CM aggregates reveal that the increasing scaling exponent of QT intervals as a function of the time scale, is an intrinsic feature at the cellular level.

SUBMITTER: Kim J 

PROVIDER: S-EPMC6403385 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Scaling and correlation properties of RR and QT intervals at the cellular level.

Kim Jiyeong J   Shah Disheet D   Potapov Ilya I   Latukka Joonas J   Aalto-Setälä Katriina K   Räsänen Esa E  

Scientific reports 20190306 1


We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis and Poincaré plots reveal remarkable similarities between the ECG and hiPSC-CM data. In particular, no statistically significant difference was found in  ...[more]

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