Details of hydrophobic entanglement between small molecules and Braun's lipoprotein within the cavity of the bacterial chaperone LolA.
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ABSTRACT:
SUBMITTER: Boags A
PROVIDER: S-EPMC6403396 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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Details of hydrophobic entanglement between small molecules and Braun's lipoprotein within the cavity of the bacterial chaperone LolA.
Boags Alister A Samsudin Firdaus F Khalid Syma S
Scientific reports 20190306 1
The cell envelope of Gram-negative bacteria is synthesized and maintained via mechanisms that are targets for development of novel antibiotics. Here we focus on the process of moving Braun's lipoprotein (BLP) from the periplasmic space to the outer membrane of E. coli, via the LolA protein. In contrast to current thinking, we show that binding of multiple inhibitor molecules inside the hydrophobic cavity of LolA does not prevent subsequent binding of BLP inside the same cavity. Rather, based on ...[more]
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