Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimura H
PROVIDER: S-EPMC6403483 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20190107 3
Hearing loss is the most common human sensory deficit. Its correction has been the goal of several gene-therapy based studies exploring a variety of interventions. Although these studies report varying degrees of success, all treatments have targeted developing inner ears in neonatal mice, a time point in the structural maturation of the cochlea prior to 26 weeks gestational age in humans. It is unclear whether cochlear gene therapy can salvage hearing in the mature organ of Corti. Herein, we re ...[more]