Dataset Information

Association of an miR-502-binding site polymorphism in the 3'-untranslated region of SET8 with colorectal cancer.

ABSTRACT: The histone methyltransferase SET8 is regulated by microRNA-502 through the binding site in its 3'-untranslated region, and the rs16917496 polymorphism at the miR-502-binding site in the SET8 gene has been implicated in a number of cancer types. The rs16917496 polymorphism including CC, CT and TT genotypes was analyzed in patients with colorectal cancer; the CC genotype was identified to be independently associated with longer post-operative survival times using multivariate analysis (relative risk, 2.406; 95% confidence interval, 1.017-5.691; P=0.046). In addition, decreased SET8 expression was associated with the SET8 CC genotype and longer survival times for patients with colorectal cancer. The results of the present study indicated that miR-502 mediates SET8 expression at least partly by altering the binding affinity between miR-502 and SET8 so as to modify the colorectal cancer outcome. The results indicate that SET8 may be a novel target for colorectal cancer therapy.

SUBMITTER: Liu S

PROVIDER: S-EPMC6403516 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Association of an miR-502-binding site polymorphism in the 3'-untranslated region of SET8 with colorectal cancer.

Liu Shuang S Dong Hailing H Wu Jianhua J Wang Cuiju C

Oncology letters 20190207 4

The histone methyltransferase SET8 is regulated by microRNA-502 through the binding site in its 3'-untranslated region, and the rs16917496 polymorphism at the miR-502-binding site in the SET8 gene has been implicated in a number of cancer types. The rs16917496 polymorphism including CC, CT and TT genotypes was analyzed in patients with colorectal cancer; the CC genotype was identified to be independently associated with longer post-operative survival times using multivariate analys ...[more]

PMID: 30881512

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Dataset Information

Association of an miR-502-binding site polymorphism in the 3'-untranslated region of SET8 with colorectal cancer.

Publications

Association of an miR-502-binding site polymorphism in the 3'-untranslated region of <i>SET8</i> with colorectal cancer.

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