Ontology highlight
ABSTRACT:
SUBMITTER: Niiyama E
PROVIDER: S-EPMC6404069 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Niiyama Eri E Uto Koichiro K Lee Chun Man CM Sakura Kazuma K Ebara Mitsuhiro M
Polymers 20180913 9
We have developed a smart anti-cancer fiber mesh that is able to control tumor-killing activity against lung adenocarcinoma precisely. The mesh is capable of carrying large loads of chemotherapeutic drug, paclitaxel (PTX), as well as magnetic nanoparticles (MNPs). The mesh generates heat when the loaded MNPs are activated in an alternating magnetic field (AMF). The mesh is thermo-responsive, so the heat generated can be also used to trigger PTX release from the mesh. An electrospinning method wa ...[more]