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Aqueous olefin metathesis: recent developments and applications.

ABSTRACT: Olefin metathesis is one of the most powerful C-C double-bond-forming reactions. Metathesis reactions have had a tremendous impact in organic synthesis, enabling a variety of applications in polymer chemistry, drug discovery and chemical biology. Although challenging, the possibility to perform aqueous metatheses has become an attractive alternative, not only because water is a more sustainable medium, but also to exploit biocompatible conditions. This review focuses on the progress made in aqueous olefin metatheses and their applications in chemical biology.

SUBMITTER: Sabatino V

PROVIDER: S-EPMC6404410 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Aqueous olefin metathesis: recent developments and applications.

Sabatino Valerio V Ward Thomas R TR

Beilstein journal of organic chemistry 20190214

Olefin metathesis is one of the most powerful C-C double-bond-forming reactions. Metathesis reactions have had a tremendous impact in organic synthesis, enabling a variety of applications in polymer chemistry, drug discovery and chemical biology. Although challenging, the possibility to perform aqueous metatheses has become an attractive alternative, not only because water is a more sustainable medium, but also to exploit biocompatible conditions. This review focuses on the progress made in aque ...[more]

PMID: 30873229

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