CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.
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ABSTRACT:
SUBMITTER: Shentu YP
PROVIDER: S-EPMC6405315 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.
Shentu Yang-Ping YP Hu Wen-Ting WT Zhang Qing Q Huo Yuda Y Liang Jia-Wei JW Liuyang Zhen-Yu ZY Zhou Huan H Wei Hui H Ke Dan D Wang Xiao-Chuan XC Wang Jian-Zhi JZ Man Heng-Ye HY Westermarck Jukka J Liu Rong R
Neurobiology of aging 20181206
Reactive astrogliosis and early synaptic degeneration are 2 characteristic hallmarks in Alzheimer's disease (AD) brains, but a direct link between the 2 events has not been established. Here, we show that cancerous inhibitor of PP2A (CIP2A), a cancerous protein with high expression level in astrocytes, is upregulated in patients with AD and 3xTg-AD transgenic mice. Overexpression of CIP2A in astrocytes through adeno-associated virus infection both in cultured cells and in mice brains results in ...[more]
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