Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes.
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ABSTRACT:
SUBMITTER: Penning TM
PROVIDER: S-EPMC6405412 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes.
Penning Trevor M TM Wangtrakuldee Phumvadee P Auchus Richard J RJ
Endocrine reviews 20190401 2
Aldo-keto reductases (AKRs) are monomeric NAD(P)(H)-dependent oxidoreductases that play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C enzymes acting as 3-ketosteroid, 17-ketosteroid, and 20-ketosteroid reductases are involved in the prereceptor regulation of ligands for the androgen, estrogen, and progesterone receptors and are considered drug targets to treat steroid hormone-dependent malignancies and endocrine disorders. In contrast, AKR1D1 is the only known ste ...[more]
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