Ontology highlight
ABSTRACT:
SUBMITTER: Carballo-Carbajal I
PROVIDER: S-EPMC6405777 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Carballo-Carbajal Iria I Laguna Ariadna A Romero-Giménez Jordi J Cuadros Thais T Bové Jordi J Martinez-Vicente Marta M Parent Annabelle A Gonzalez-Sepulveda Marta M Peñuelas Núria N Torra Albert A Rodríguez-Galván Beatriz B Ballabio Andrea A Hasegawa Takafumi T Bortolozzi Analía A Gelpi Ellen E Vila Miquel M
Nature communications 20190307 1
In Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD. The contribution of neuromelanin to PD pathogenesis remains unknown because, unlike humans, common laboratory animals lack neuromelanin. Synthesis of peripheral melanins is mediated by tyrosinase, an enzyme also present at low levels in the brain. Here we repo ...[more]