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Differential gene expression induced by Verteporfin in endometrial cancer cells.

ABSTRACT: Endometrial cancer (EMCA) is a clinically heterogeneous disease. Previously, we tested the efficacy of Verteporfin (VP) in EMCA cells and observed cytotoxic and anti-proliferative effects. In this study, we analyzed RNA sequencing data to investigate the comprehensive transcriptomic landscape of VP treated Type 1 EMCA cell lines, including HEC-1-A and HEC-1-B. There were 549 genes with differential expression of two-fold or greater and P?

SUBMITTER: Bang LG

PROVIDER: S-EPMC6405995 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Differential gene expression induced by Verteporfin in endometrial cancer cells.

Bang Lisa Gahyun LG Dasari Venkata Ramesh VR Kim Dokyoon D Gogoi Radhika P RP

Scientific reports 20190307 1

Endometrial cancer (EMCA) is a clinically heterogeneous disease. Previously, we tested the efficacy of Verteporfin (VP) in EMCA cells and observed cytotoxic and anti-proliferative effects. In this study, we analyzed RNA sequencing data to investigate the comprehensive transcriptomic landscape of VP treated Type 1 EMCA cell lines, including HEC-1-A and HEC-1-B. There were 549 genes with differential expression of two-fold or greater and P < 0.05 after false discovery rate correction for the HEC-1 ...[more]

PMID: 30846786

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Project description:Verteporfin (trade name Visudyne) is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 689 nm[1] in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. Recently, it was reported that VP has chemotherapeutic effect in cancer. To identify the gene expression profile in gastric cancer cells by VP, we performed microarray.

2017-12-26 | GSE77982 | GEO

Association between differential gene expression and body mass index among endometrial cancers from The Cancer Genome Atlas Project.

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