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Differential gene expression induced by Verteporfin in endometrial cancer cells.

ABSTRACT: Endometrial cancer (EMCA) is a clinically heterogeneous disease. Previously, we tested the efficacy of Verteporfin (VP) in EMCA cells and observed cytotoxic and anti-proliferative effects. In this study, we analyzed RNA sequencing data to investigate the comprehensive transcriptomic landscape of VP treated Type 1 EMCA cell lines, including HEC-1-A and HEC-1-B. There were 549 genes with differential expression of two-fold or greater and P?

SUBMITTER: Bang LG 

PROVIDER: S-EPMC6405995 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Differential gene expression induced by Verteporfin in endometrial cancer cells.

Bang Lisa Gahyun LG   Dasari Venkata Ramesh VR   Kim Dokyoon D   Gogoi Radhika P RP  

Scientific reports 20190307 1

Endometrial cancer (EMCA) is a clinically heterogeneous disease. Previously, we tested the efficacy of Verteporfin (VP) in EMCA cells and observed cytotoxic and anti-proliferative effects. In this study, we analyzed RNA sequencing data to investigate the comprehensive transcriptomic landscape of VP treated Type 1 EMCA cell lines, including HEC-1-A and HEC-1-B. There were 549 genes with differential expression of two-fold or greater and P < 0.05 after false discovery rate correction for the HEC-1  ...[more]

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