Dataset Information

Delayed Antibiotic Therapy and Organ Dysfunction in Critically Ill Septic Patients in the Emergency Department.

ABSTRACT:

Background

We investigated the effect of antibiotic timing on outcomes based on changes in surrogate markers of organ failure, including platelet, serum bilirubin, serum creatinine levels, and the PaO?/FiO? (P/F) ratio.

Methods

This was a single-center, retrospective observational study of critically ill septic patients who presented to the emergency department (ED). The study period extended from August 2008 to September 2016. The primary outcomes included changes in platelet, serum bilirubin, serum creatinine levels, and the P/F ratio (?-platelet, ?-serum bilirubin, ?-serum creatinine, and ?-P/F ratio were calculated as values measured on Day 3; values measured at ED enrollment). A multivariable linear regression model was developed to assess variables related to outcomes (?-platelet, ?-serum bilirubin, ?-serum creatinine, and ?-P/F ratio).

Results

We analyzed 1784 patients who met the inclusion criteria. The overall 28-day mortality was 14% (n = 256/1784). On multivariable linear regression analysis, the hourly delay in antibiotic therapy was significantly associated with a decrease in ?-platelet count (coefficient, -1.741; standard error, 0.740; p = 0.019), and an increase in ?-serum bilirubin (coefficient, 0.054; standard error, 0.021; p = 0.009). In contrast, it was not associated with ?-creatinine (coefficient, 0.008; standard error, 0.010; p = 0.434) or the ?-P/F ratio (coefficient, -0.797; standard error, 1.858; p = 0.668).

Conclusion

The hourly delay of antibiotic therapy was associated with decreased platelet count and increased serum bilirubin concentration in critically ill septic patients during the first three days of ED admission.

SUBMITTER: Hwang SY

PROVIDER: S-EPMC6406307 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Publications

Delayed Antibiotic Therapy and Organ Dysfunction in Critically Ill Septic Patients in the Emergency Department.

Hwang Sung Yeon SY Shin Jikyoung J Jo Ik Joon IJ Park Jong Eun JE Yoon Hee H Cha Won Chul WC Sim Min Seob MS Shin Tae Gun TG

Journal of clinical medicine 20190208 2

<h4>Background</h4>We investigated the effect of antibiotic timing on outcomes based on changes in surrogate markers of organ failure, including platelet, serum bilirubin, serum creatinine levels, and the PaO₂/FiO₂ (P/F) ratio.<h4>Methods</h4>This was a single-center, retrospective observational study of critically ill septic patients who presented to the emergency department (ED). The study period extended from August 2008 to September 2016. The primary outcomes included changes in platelet, se ...[more]

PMID: 30744073

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Dataset Information

Delayed Antibiotic Therapy and Organ Dysfunction in Critically Ill Septic Patients in the Emergency Department.

Background

Methods

Results

Conclusion

Publications

Delayed Antibiotic Therapy and Organ Dysfunction in Critically Ill Septic Patients in the Emergency Department.

Similar Datasets

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