Ontology highlight
ABSTRACT:
SUBMITTER: Coni S
PROVIDER: S-EPMC6406590 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Coni Sonia S Di Magno Laura L Serrao Silvia Maria SM Kanamori Yuta Y Agostinelli Enzo E Canettieri Gianluca G
Cells 20190211 2
Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation,due to somatic or germline mutations of genes encoding pathway components, causes Basal CellCarcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at theidentification of druggable vulnerabilities of the Hedgehog signaling, leading to the identificationof various compounds with variable efficacy and/or safety. Emerging evidence shows that anaberrant polyamine metabolism is a hallmark of ...[more]