Age dependent effects of NELL-1 isoforms on bone marrow stromal cells.
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ABSTRACT:
SUBMITTER: Meyers CA
PROVIDER: S-EPMC6406628 | biostudies-literature | 2019 Mar-Apr
REPOSITORIES: biostudies-literature
Publications
Age dependent effects of NELL-1 isoforms on bone marrow stromal cells.
Meyers Carolyn A CA Sun Zhibo Z Chang Leslie L Ding Catherine C Lu Amy A Ting Kang K Pang Shen S James Aaron W AW
Journal of orthopaedics 20190228 2
NELL-1 is an osteogenic protein first discovered to control ossification of the cranium. NELL-1 exists in at least two isoforms. The full-length NELL-1 contains 810 amino acid (aa) (NELL-1810), the N-terminal-truncated NELL-1 isoform contains 570 aa (NELL-1570). The differences in cellular effects between NELL-1 isoforms are not well understood. Methods: Here, BMSC were derived from adult or aged mice, followed by overexpression of NELL-1810 or NELL-1570. Cell morphology, proliferation, and gene ...[more]
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