Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.
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ABSTRACT:
SUBMITTER: van der Plaat DA
PROVIDER: S-EPMC6407273 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population.
van der Plaat Diana A DA Vonk Judith M JM Lahousse Lies L de Jong Kim K Faiz Alen A Nedeljkovic Ivana I Amin Najaf N van Diemen Cleo C CC Brusselle Guy G GG Bossé Yohan Y Brandsma Corry-Anke CA Hao Ke K Paré Peter D PD van Duijn Cornelia M CM Postma Dirkje S DS Boezen H Marike HM
BMC pulmonary medicine 20190307 1
<h4>Background</h4>Airflow obstruction is a hallmark of chronic obstructive pulmonary disease (COPD), and is defined as either the ratio between forced expiratory volume in one second and forced vital capacity (FEV<sub>1</sub>/FVC) < 70% or < lower limit of normal (LLN). This study aimed to assess the overlap between genome-wide association studies (GWAS) on airflow obstruction using these two definitions in the same population stratified by smoking.<h4>Methods</h4>GWASes were performed in the L ...[more]
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