Ontology highlight
ABSTRACT:
SUBMITTER: Chikowore T
PROVIDER: S-EPMC6407309 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Journal of clinical & translational endocrinology 20190228
<h4>Aim</h4>To evaluate the association between loss-of-function (LOF) <i>PCSK9</i> variants (A433T/rs28362263 and C679X/rs28362286) and biomarkers of cardiometabolic risk, specifically fasting glucose and low density lipoprotein cholesterol (LDL-C) concentrations.<h4>Methods</h4>Our study comprised 757 male and female black South African adolescents (mean age 18.0 ± 0.5 years) who are part of the Birth to Twenty Plus Cohort and had been genotyped for the two above-mentioned variants. Anthropome ...[more]