Ontology highlight
ABSTRACT:
SUBMITTER: Di Paolo ML
PROVIDER: S-EPMC6407594 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Di Paolo Maria Luisa ML Cervelli Manuela M Mariottini Paolo P Leonetti Alessia A Polticelli Fabio F Rosini Michela M Milelli Andrea A Basagni Filippo F Venerando Rina R Agostinelli Enzo E Minarini Anna A
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1-9) or methoctramine (10-14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and acetylpolyamine oxidase (PAOX). Compound 2 turned out to be the best substrate for PAOX, having the highest affinity and catalytic efficiency with respect to its physiological substrates. Methoctramine (10), a well-known muscarinic M<sub>2</sub> recep ...[more]