Ontology highlight
ABSTRACT:
SUBMITTER: Fulciniti M
PROVIDER: S-EPMC6407615 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Fulciniti Mariateresa M Lin Charles Y CY Samur Mehmet K MK Lopez Michael A MA Singh Irtisha I Lawlor Matthew A MA Szalat Raphael E RE Ott Christopher J CJ Avet-Loiseau Herve' H Anderson Kenneth C KC Young Richard A RA Bradner James E JE Munshi Nikhil C NC
Cell reports 20181201 13
The relationship between promoter proximal transcription factor-associated gene expression and super-enhancer-driven transcriptional programs are not well defined. However, their distinct genomic occupancy suggests a mechanism for specific and separable gene control. We explored the transcriptional and functional interrelationship between E2F transcription factors and BET transcriptional co-activators in multiple myeloma. We found that the transcription factor E2F1 and its heterodimerization par ...[more]