Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Junco-Clemente P
PROVIDER: S-EPMC6407626 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Garcia-Junco-Clemente Pablo P Tring Elaine E Ringach Dario L DL Trachtenberg Joshua T JT
Cell reports 20190201 9
Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition. We find that fast-spiking, parvalbumin-expressing inhibitory neurons, which exert state-dependent control of network gain and spike patterns, cluster into two stable and functionally distinct subnetworks that are differentially engaged by ascendi ...[more]