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The association between body lead levels and childhood rickets: A meta-analysis based on Chinese cohort.


ABSTRACT: China has serious lead pollution and a high incidence of childhood rickets. High lead levels have been reported in childhood rickets, but the results were inconsistent.To evaluate the association between body lead levels and childhood rickets.After a systematic literature search, we identified 15 studies determining body lead levels between rickets children and healthy controls, and 4 studies focusing on the cases of different disease severity. Standard mean differences (SMD) and the corresponding 95% confidence intervals (CI) were pooled to compare the lead levels between different groups.Sixteen case-control studies were included with a total of 5082 cases and 6054 controls. Compared with healthy controls, the body lead levels in rickets children were significantly higher (SMD (95%CI): 0.67 (0.41-0.93)), and subgroup analyses showed consistent results. The cases with moderate-to-severe disease activity also had a significantly higher lead level than mild-to-moderate cases (SMD (95%CI): 0.64 (0.31-0.97)).This meta-analysis suggested an association between body lead levels and childhood rickets, and lead exposure might be a risk factor for rickets.

SUBMITTER: Zhang YF 

PROVIDER: S-EPMC6407931 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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The association between body lead levels and childhood rickets: A meta-analysis based on Chinese cohort.

Zhang Yong-Fang YF   Xu Jiang-Wei JW   Yang Yao Y   Huang Xueqin X   Yu Xin-Qiao XQ  

Medicine 20190201 8


China has serious lead pollution and a high incidence of childhood rickets. High lead levels have been reported in childhood rickets, but the results were inconsistent.To evaluate the association between body lead levels and childhood rickets.After a systematic literature search, we identified 15 studies determining body lead levels between rickets children and healthy controls, and 4 studies focusing on the cases of different disease severity. Standard mean differences (SMD) and the correspondi  ...[more]

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